BDBM373098 1-(2-methyl-4- phenylpyrimidin-5- yl)-3-naphthalen-1- ylurea::US9896447, Compound 15

SMILES Cc1ncc(NC(=O)Nc2cccc3ccccc23)c(n1)-c1ccccc1

InChI Key InChIKey=QTGKTWMSCVUXHK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 373098   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373098(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-naphthalen...)
Affinity DataIC50:  4.10E+3nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNT-3 growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM373098(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-naphthalen...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373098(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-naphthalen...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB