BDBM373712 US10246444, Example 92
SMILES OC[C@H](O)COc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)CC1CSSC1
InChI Key InChIKey=UVWRRZRGHPHHLL-QHCPKHFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 373712
TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sabila Biosciences
Curated by ChEMBL
Sabila Biosciences
Curated by ChEMBL
Affinity DataKd: 6nMAssay Description:Inhibition of recombinant human wild type partial length HER4 (690 to 994 residues) expressed in bacterial expression system by competitive binding a...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sabila Biosciences
Curated by ChEMBL
Sabila Biosciences
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:Inhibition of HER2 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sabila Biosciences
Curated by ChEMBL
Sabila Biosciences
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 419nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of EGFR ex19del mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus expression system by competitive binding a...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus expression system by competit...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of recombinant human N-terminal His-tagged HER2 (676 to 1255 residues) expressed in baculovirus expression system by competitive binding a...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sabila Biosciences
Curated by ChEMBL
Sabila Biosciences
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HER4 (676 to 1308 residues) expressed in baculovirus expression system by competitive binding a...More data for this Ligand-Target Pair
Affinity DataKd: 9.20nMAssay Description:Inhibition of recombinant human partial length EGFR L858R mutant (669 to 1011 residues) expressed in bacterial expression system by competitive bindi...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-3(Homo sapiens (Human))
Sabila Biosciences
Curated by ChEMBL
Sabila Biosciences
Curated by ChEMBL
Affinity DataKd: 380nMAssay Description:Inhibition of recombinant human wild type partial length HER3 (684 to 987 residues) expressed in mammalian expression system by competitive binding a...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-751,753-758,760-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair