BDBM418222 2-[(1R)-5-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1- methyl-3-oxo-2,3-dihydro-1H-isoindol- 2-yl]-N-[(1S)-1-(3-fluoro-5- methoxyphenyl)-2- hydroxyethyl]acetamide::US10457669, Example 987::US11001575, Example 987

SMILES CNc1ncc(Cl)c(n1)-c1ccc2[C@@H](C)N(CC(=O)N[C@H](CO)c3cc(F)cc(OC)c3)C(=O)c2c1

InChI Key InChIKey=ZFMYGMJJCFXLOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418222   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418222(2-[(1R)-5-[5-chloro-2- (methylamino)pyrimidin-4-yl...)
Affinity DataIC50: 4.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418222(2-[(1R)-5-[5-chloro-2- (methylamino)pyrimidin-4-yl...)
Affinity DataIC50: 4.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent