BDBM429615 US10550091, No. LC-24::US10947203, No. LC-24

SMILES COc1cc(OC)c(cc1C)-n1nnc(c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=HXRSXIPYPZGCEK-UHFFFAOYSA-N

Data  4 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 429615   

TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataIC50:  340nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataEC50:  880nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataIC50:  340nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataIC50:  750nMAssay Description:Binding affinity to human PXRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataEC50:  880nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429615(US10550091, No. LC-24 | US10947203, No. LC-24)
Affinity DataEC50:  880nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB