BDBM4355 (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide::CHEMBL308048::benzylidenemalononitrile (BMN) deriv. 39

SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N

InChI Key InChIKey=ILLYSIXRHPOKIQ-VMPITWQZSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4355   

TargetGenome polyprotein(Dengue virus 2)
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataKi:  3.57E+4nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Dengue virus 2)
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataKi:  3.57E+4nMAssay Description:Binding affinity to DENV2 NS2B/NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProthrombin(Homo sapiens (Human))
University Of Heidelberg

Curated by ChEMBL
LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataKi:  1.02E+5nMAssay Description:Inhibition of human thrombin using Boc-VPR-AMC as substrate compound preincubated for 15 mins before substrate addition measured up to 10 mins by spe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataIC50:  1.00E+6nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataIC50:  8.00E+5nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Affinity DataIC50:  8.00E+5nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed