BDBM4394 4-Anilidoquinazoline deriv. 9a::6,7-dimethoxy-N-(3-methoxyphenyl)quinazolin-4-amine::Methoxy Aniline 1

SMILES COc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1

InChI Key InChIKey=FMZCWRYXPHDICO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4394   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4394(4-Anilidoquinazoline deriv. 9a | 6,7-dimethoxy-N-(...)
Affinity DataIC50:  253nMpH: 7.4 T: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4394(4-Anilidoquinazoline deriv. 9a | 6,7-dimethoxy-N-(...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4394(4-Anilidoquinazoline deriv. 9a | 6,7-dimethoxy-N-(...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4394(4-Anilidoquinazoline deriv. 9a | 6,7-dimethoxy-N-(...)
Affinity DataIC50:  6.30E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed