BDBM4397 4-Anilidoquinazoline deriv. 12a::6-chloro-N-(3-chlorophenyl)quinazolin-4-amine

SMILES Clc1cccc(Nc2ncnc3ccc(Cl)cc23)c1

InChI Key InChIKey=QKCFZLIUAVWYRM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4397   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4397(4-Anilidoquinazoline deriv. 12a | 6-chloro-N-(3-ch...)
Affinity DataIC50:  2.70E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4397(4-Anilidoquinazoline deriv. 12a | 6-chloro-N-(3-ch...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM4397(4-Anilidoquinazoline deriv. 12a | 6-chloro-N-(3-ch...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed