BDBM470342 5-fluoro-4-[3-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[3-(trifluoromethyl)phenyl]-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide::US10815215, Example 4::US11130745, Example 4::US11713304, Example 4

SMILES CC(C)n1c(C)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2cccc(c2)C(F)(F)F)c1=O

InChI Key InChIKey=CFLJPCQTERMGAW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 470342   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al. 196...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 1.10E+3nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 2.27E+3nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 2.27E+3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 470342BDBM470342(US10815215, Example 4 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 2.27E+3nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent