BDBM4812 (3Z)-3-({3,5-dimethyl-4-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrol-2-yl}methylidene)-2,3-dihydro-1H-indol-2-one::SU5416 analog 5c

SMILES CN1CCN(CCCc2c(C)[nH]c(\C=C3/C(=O)Nc4ccccc34)c2C)CC1

InChI Key InChIKey=LPLGZUZPKACGSS-HKWRFOASSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4812   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sugen

LigandPNGBDBM4812((3Z)-3-({3,5-dimethyl-4-[3-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

LigandPNGBDBM4812((3Z)-3-({3,5-dimethyl-4-[3-(4-methylpiperazin-1-yl...)
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

LigandPNGBDBM4812((3Z)-3-({3,5-dimethyl-4-[3-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  60nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4812((3Z)-3-({3,5-dimethyl-4-[3-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  4.20E+3nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed