BDBM50029770 4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide::4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide::ACETYLSULFAMETHOXAZOLE::BACTRIM::CHEMBL443::COTRIM::GANTANOL::GANTANOL-DS::RO 4-2130::SEPTRA::SULFAMETHOPRIM::SULFAMETHOPRIM-DS::SULFAMETHOXAZOLE SODIUM::SULFATRIM::SULFATRIM-DS::SULFATRIM-SS::SULMEPRIM::SULPHAMETHOXAZOLE::TRIMETH/SULFA::UROBAK

SMILES Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)N

InChI Key InChIKey=JLKIGFTWXXRPMT-UHFFFAOYSA-N

Data  1 KI  16 IC50  1 Kd

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50029770   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataKi:  10.1nMAssay Description:Inhibition constant for human immunodeficiency virus type 1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii in the prence of 100 micro M PABA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataKd:  577nMAssay Description:Binding affinity for human immunodeficiency virus type 1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei brucei)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 3.33E+5nMAssay Description:Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 3.33E+5nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 3.33E+5nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-4(Human)
University of South Carolina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029770BDBM50029770(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of PAD4 by ABPP-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed