BDBM50033422 CHEMBL3357688

SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C

InChI Key InChIKey=GQRWEJRYCBEXLY-UHFFFAOYSA-N

Data  7 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50033422   

TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  1.40nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  6nMAssay Description:Inhibition of Leishmania major NMT L421Q mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft...More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  8.5nMAssay Description:Inhibition of Leishmania major NMT H398N mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  13nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN...More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  40nMAssay Description:Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataIC50:  25nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair