BDBM50034435 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-2,3-dihydro-oxazol-5-yl)-amide::5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide (BMS 182874)::BMS-182874::CHEMBL267458
SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C
InChI Key InChIKey=MJRGSRRZKSJHOE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50034435
Affinity DataKi: 48nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 55nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Binding affinity of the compound towards ET1 receptor was determined in A10 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Inhibition of Human Endothelin A receptor expressed in CHO Cells.More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Tested for binding affinity for human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
TargetEndothelin receptor type B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >2.00E+5nMAssay Description:Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >2.00E+5nMAssay Description:Selectivity for the ET-A receptor over ETB receptor was observed in rat cerebellar membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against Endothelin A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Binding affinity against human ETB receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 570nMAssay Description:Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsMore data for this Ligand-Target Pair