BDBM50045775 (3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::3-((3R,4R)-1-((S)-3-cyclohexyl-3-hydroxypropyl)-3,4-dimethylpiperidin-4-yl)phenol::3-[(3R,4R)-1-((S)-3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::CHEMBL300662::LY-255582
SMILES C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
InChI Key InChIKey=LVVHEFJXPXAUDD-BULFRSBZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50045775
Affinity DataKi: 0.0210nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
Affinity DataKi: 0.0430nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.312nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding in Guinea pig caudate stimulated by SMC-80 (Opio...More data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Inhibition of binding of [3H]DAMGO to Opioid receptor mu 1 in guinea pig membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding in Guinea pig caudate stimulated by U69,593 to O...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissueMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]diprenorphine from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Binding affinity to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Displacement of [3H]bremazocine from human delta opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Displacement of [3H]bremazocine from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Binding affinity to human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Binding affinity towards delta-opioid receptor by displacement of [3H]-DADL in rat brain homogenatesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Inhibition of binding of [3H]U69, 593 to Opioid receptor kappa 1 in guinea pig membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 of guinea pig membranesMore data for this Ligand-Target Pair
Affinity DataKi: 198nMAssay Description:Inhibition of binding of [3H]DADLE to Opioid receptor delta 1 in guinea pig membranesMore data for this Ligand-Target Pair
Affinity DataKi: 198nMAssay Description:Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly
Curated by ChEMBL
Eli Lilly
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Tested for affinity against dopamine autoreceptor using [3H]apomorphine in rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Eli Lilly
Curated by ChEMBL
Eli Lilly
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Tested for affinity against alpha-adrenergic using [3H]WB-4101 in rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Tested for affinity against dopamine D1 receptor using [3H]-SCH-23,390 in rat brainMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Eli Lilly
Curated by ChEMBL
Eli Lilly
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Tested for affinity against alpha-2-adrenergic using [3H]clonidine in rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Tested for affinity against dopamine D2 receptor using [3H]-SCH-23,390 in rat brainMore data for this Ligand-Target Pair