BDBM50064888 3',5-dihydroxy-3,4',7-trimethoxyflavone::5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one::CHEMBL74898

SMILES COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O

InChI Key InChIKey=KPCRYSMUMBNTCK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50064888   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  680nMAssay Description:Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  460nMAssay Description:Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed