BDBM50068379 5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan::CHEMBL330751::cyno-C5'-guanidinyl naltrindole

SMILES NC(Nc1ccc2[nH]c3[C@@H]4Oc5c6c(CC7N(CC8CC8)CC[C@@]46[C@@]7(O)Cc3c2c1)ccc5O)=NC#N

InChI Key InChIKey=XNDXLWXMLIMVAF-ZRWUOUSXSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50068379   

TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  0.270nMAssay Description:Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  0.290nMAssay Description:Mutant factor against mu-[K303E] with Opioid receptor kappa 1 for binding affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  2.5nMAssay Description:Mutant factor of the compound against kappa[E297K] with Opioid receptor kappa 1 for binding affinity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  4nMAssay Description:Effect on binding affinity of mutational exchange of Lys303 in the Opioid receptor mu 1 in transiently expressed rat cos-7 cells activity expressed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  4.46nMAssay Description:Binding affinity on HEK-293 cells transiently transfected with plasmids encoding the rat Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  9.46nMAssay Description:Binding affinity on HEK-293 cells transiently transfected with plasmids encoding the rat Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  89.8nMAssay Description:Binding affinity on HEK-293 cells transiently transfected with plasmids encoding the rat Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed