BDBM50068759 8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazolin-4-one::CHEMBL123798

SMILES COc1cccc2c1nc([nH]c2=O)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=PFWLEODBNCMHGH-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068759   

TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068759(8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazol...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50068759(8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazol...)
Affinity DataIC50:  73nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50068759(8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50068759(8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazol...)
Affinity DataIC50:  87nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50068759(8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazol...)
Affinity DataIC50:  570nMAssay Description:Inhibition of human PARP-2 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed