BDBM50074744 3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinolin-4-one::CHEMBL440453

SMILES COc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1

InChI Key InChIKey=FTEDVZPTRHFYOX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074744   

TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of EGF-dependent mouse keratinocyte MK cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of p60 c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of v-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed