BDBM50078114 (1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol::CHEMBL291020::Conduritol B Epoxide::Conduritol B Epoxide, 2::US11826435, Compound 1.2::US9056847, Conduritol B- epoxide

SMILES O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=ZHMWOVGZCINIHW-FTYOSCRSSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50078114   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  7.73E+3nM IC50:  1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  5.30E+4nM ΔG°:  -6.06kcal/mole IC50:  9.49E+3nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  1.40E+5nMAssay Description:Inactivation solutions contained a final concentration of 16.55 nM of Cerezyme (Recombinant GCase) in 200 μL of Reaction Buffer (50 mM acetate, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50:  9.49E+3nMAssay Description:Inactivation solutions contained a final concentration of 16.55 nM of Cerezyme (Recombinant GCase) in 200 μL of Reaction Buffer (50 mM acetate, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Compound was tested for inhibitory activity against beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMaltase-glucoamylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50: <1.00E+5nMAssay Description:Compound was tested for inhibitory activity against alpha-glucosidase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50:  8.90E+3nMAssay Description:Specific inhibitory activity against Glucosylceramidase in mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed