BDBM50078374 CHEMBL3414926

SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1

InChI Key InChIKey=SCRRRLBPWUHHER-HNNXBMFYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50078374   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  5nMAssay Description:Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in absence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  5nMAssay Description:Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ...More data for this Ligand-Target Pair