BDBM50084210 (R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-methylene-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL358405

SMILES COCCOc1ccc(cc1)S(=O)(=O)N1CC(=C)C[C@@H]1C(=O)NO

InChI Key InChIKey=RQEBSVZFRXVOLZ-CQSZACIVSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50084210   

TargetStromelysin-1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084210((R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-met...)
Affinity DataIC50:  69nMAssay Description:In vitro inhibition activity of human recombinant stromelysin (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084210((R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-met...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory activity against gelatinase-A (matrix metalloproteinase-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084210((R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-met...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of human recombinant collagenase-3 (Matrix metalloproteinase-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084210((R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-met...)
Affinity DataIC50: >9.99E+3nMAssay Description:In vitro inhibition of matrilysin (Matrix metalloproteinase-7, MMP-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084210((R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-met...)
Affinity DataIC50:  1.55E+3nMAssay Description:In vitro inhibition of human recombinant collagenase-1 (Matrix metalloproteinase-1, MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed