BDBM50087459 17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,7'-tetradehydro-4,5 alpha : 4',5' alpha-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-3,3',14,14'-tetrol

SMILES CC(=O)N1CC[C@@]23[C@H]4Oc5c2c(CC1[C@]3(O)Cc1c2C[C@@]3(O)C6Cc7ccc(O)c8O[C@@H](c2[nH]c41)[C@]3(CCN6CC1CC1)c78)ccc5O

InChI Key

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50087459   

TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50087459(17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,...)
Affinity DataKi:  23.6nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50087459(17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,...)
Affinity DataKi:  42nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against K303E Opioid receptor mu 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50087459(17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,...)
Affinity DataKi:  102nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor mu 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50087459(17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,...)
Affinity DataKi:  104nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against E297K mutant Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50087459(17-cyclopropylmethyl-17'-acetyl-3'-hydroxy-6,6',7,...)
Affinity DataKi:  104nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against E297A mutant Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed