BDBM50100516 CHEMBL3326315

SMILES Oc1ccc(NS(=O)(=O)c2cc(c3cccc4C(=O)Sc2c34)S(=O)(=O)Nc2ccc(O)cc2)cc1

InChI Key InChIKey=CLBCQYRZNKJNMZ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 90 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100516   

TargetTumor necrosis factor(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50100516(CHEMBL3326315)
Affinity DataIC50:  2.53E+4nMAssay Description:Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50100516(CHEMBL3326315)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed