BDBM50103599 CHEBI:50694::Minocycline

SMILES CN(C)c1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O

InChI Key InChIKey=DYKFCLLONBREIL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50103599   

TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetMatrilysin(Human)
Jadavpur University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103599BDBM50103599(CHEBI:50694 | Minocycline)
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed