BDBM50108697 1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)]::1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[2H-1-benzopyran-2,4'-piperidine]::CHEMBL147431

SMILES Fc1ccc(CCN2CCC3(CC2)CCc2ccccc2O3)c(F)c1

InChI Key InChIKey=HMDHSUIMQILHRP-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50108697   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  0.720nMAssay Description:Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  110nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  450nMAssay Description:Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108697(1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chr...)
Affinity DataKi:  750nMAssay Description:Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed