BDBM50109532 CHEMBL3601223

SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1

InChI Key InChIKey=UGXCBYVBIJACEK-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50109532   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of JAK3 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of ITK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  794nMAssay Description:Inhibition of BTK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  409nMAssay Description:Inhibition of wild type EGFR (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  13nMAssay Description:Inhibition of FLT3 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  896nMAssay Description:Inhibition of JAK1 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  36nMAssay Description:Inhibition of TXK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  157nMAssay Description:Inhibition of BLK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  49nMAssay Description:Inhibition of TTK (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed