BDBM50111471 CHEMBL3604910

SMILES CCC(=O)Nc1ccc2c(Nc3cc[nH]n3)nc(nc2c1)-c1ccccc1

InChI Key InChIKey=PXXRUTHYKIZABM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50111471   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50111471(CHEMBL3604910)
Affinity DataIC50:  60nMAssay Description:Inhibition of cSrc T338M mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50111471(CHEMBL3604910)
Affinity DataIC50:  336nMAssay Description:Inhibition of wild type cSrc (251 to 533 residues) (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50111471(CHEMBL3604910)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50111471(CHEMBL3604910)
Affinity DataIC50:  48nMAssay Description:Inhibition of cSrc T338M/S345C mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed