BDBM50116391 2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL27085

SMILES Cc1[nH]c(=O)c2c3nc(Nc4c(Cl)cccc4Cl)[nH]c3ccc2c1C

InChI Key InChIKey=YDEDKRCWCCZXBE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50116391   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Syk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) with 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of c-SRC with 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed