BDBM50123581 CHEMBL3622207

SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2nscc12)-c1cnn(C)c1

InChI Key InChIKey=UVAKITWUHZQGNR-NXEZZACHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123581   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123581(CHEMBL3622207)
Affinity DataIC50:  40nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123581(CHEMBL3622207)
Affinity DataIC50:  247nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123581(CHEMBL3622207)
Affinity DataIC50:  290nMAssay Description:Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123581(CHEMBL3622207)
Affinity DataIC50:  800nMAssay Description:Inhibition of aurora A kinase (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed