BDBM50124868 CHEMBL3622958

SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(C)c3c2)n1

InChI Key InChIKey=WVDKJJLIGILVRJ-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50124868   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  1.70nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  56nMAssay Description:Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  653nMT: 2°CAssay Description:Inhibition of KDR (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  1.38E+5nMT: 2°CAssay Description:Inhibition of human JAK2 pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  418nMT: 2°CAssay Description:Inhibition of JAK3 (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  985nMT: 2°CAssay Description:Inhibition of Aurora B kinase (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50:  9.96E+5nMT: 2°CAssay Description:Inhibition of purified full-length human ZAP70 pre-incubated for 30 mins at room temperature before UlighTM-PolyGT peptide substrate addition and mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed