BDBM50133870 CHEBI:78030::CHEMBL3188386::US10251893, Compound 86
SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
InChI Key InChIKey=XXYGTCZJJLTAGH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50133870
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by ChEMBL
Experimental Therapeutics Centre
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by ChEMBL
Experimental Therapeutics Centre
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of porcupine (unknown origin)More data for this Ligand-Target Pair