BDBM50138827 CHEMBL3752711::US10233190, Example 1418

SMILES O[C@H](C[C@H]1c2ccccc2-c2cncn12)C1CCCCC1

InChI Key InChIKey=YTRRAUACYORZLX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50138827   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50138827(CHEMBL3752711 | US10233190, Example 1418)
Affinity DataIC50: 60nMAssay Description:Inhibition of human IDO1 using tryptophan as substrate assessed as reduction in N-formylkynurenine formation preincubated with compound for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50138827(CHEMBL3752711 | US10233190, Example 1418)
Affinity DataIC50: 110nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50138827(CHEMBL3752711 | US10233190, Example 1418)
Affinity DataIC50: 370nMAssay Description:Inhibition of full length N-terminal/C-terminal his-tagged human TDO expressed in Escherichia coli BL21 (DE3) assessed as N-formylkynurenine formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50138827(CHEMBL3752711 | US10233190, Example 1418)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in M15(pREP4) cells using L-tryptophan as substrate assessed as conversion of N-formylkynurenine to ky...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50138827(CHEMBL3752711 | US10233190, Example 1418)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent