BDBM50164530 CHEMBL3797232

SMILES ONC(=O)c1ccc(Cl)c(NC(=O)c2ccc(Cl)cc2Cl)c1

InChI Key InChIKey=UYUPOQDZJBPUTQ-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50164530   

TargetHistone deacetylase 1(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50164530(CHEMBL3797232)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition measured after 20 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50164530(CHEMBL3797232)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of recombinant human HDAC8 using Fluor de Lys as substrate preincubated for 90 mins followed by BML-KI176 addition measured after 45 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Washington University

Curated by ChEMBL
LigandPNGBDBM50164530(CHEMBL3797232)
Affinity DataIC50:  191nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50164530(CHEMBL3797232)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant human HDAC6 using Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition measured after 20 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Washington University

Curated by ChEMBL
LigandPNGBDBM50164530(CHEMBL3797232)
Affinity DataIC50:  191nMAssay Description:Inhibition of recombinant Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate preincubated for 90 mins followed b...More data for this Ligand-Target Pair