BDBM50188569 8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione::CHEMBL378598

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(Cc2cc(ccc2Cl)C(F)(F)F)c1

InChI Key InChIKey=QUPSOSYMAZFQHU-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50188569   

TargetAdenosine receptor A2b(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  22nMAssay Description:Antagonist activity against human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  54nMAssay Description:Antagonist activity against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  1.20E+3nMAssay Description:Antagonist activity against human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  1.40E+3nMAssay Description:Antagonist activity against human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2a receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50188569(8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyraz...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed