BDBM50192222 3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)thiophene-2-carboxylic acid::CHEMBL218347

SMILES CN(C)c1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=OLCMVCLJBGXVTE-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192222   

TargetGlutamate receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192222(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Affinity DataEC50:  474nMAssay Description:Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192222(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Affinity DataEC50: >3.00E+3nMAssay Description:Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192222(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Affinity DataEC50:  2.85E+3nMAssay Description:Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192222(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Affinity DataEC50:  176nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed