BDBM50192821 CHEMBL2133556
SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
InChI Key InChIKey=NCZYSQOTAYFTNM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50192821
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Who...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Antagonist activity at TRPV4 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair