BDBM50207345 CHEMBL3944077

SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C#CC4CC4)c(F)c3)c3OCCOc3c12

InChI Key InChIKey=NDHWTYVEETWKDT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50207345   

TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50207345(CHEMBL3944077)
Affinity DataIC50:  51nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in interleukin-1 beta-induced PGE2 production incubated for 30 mins followed by IL-1b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50207345(CHEMBL3944077)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 incubated for 10 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed