BDBM50239069 CHEMBL4079036

SMILES COc1nc2ccc(cc2c(Cl)c1-c1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=GBSZBTDJEFDZLG-UHFFFAOYSA-N

Data  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239069   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239069(CHEMBL4079036)
Affinity DataKd:  37nMAssay Description:Displacement of 1,8-ANS from recombinant human RORgammat LBD expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of co-activator SR...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239069(CHEMBL4079036)
Affinity DataEC50:  240nMAssay Description:Transactivation of RORgammat in human Th17 cells assessed as increase in IL17A productionMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239069(CHEMBL4079036)
Affinity DataEC50:  49nMAssay Description:Transactivation of GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by Dual...More data for this Ligand-Target Pair