BDBM50239943 CHEMBL4099869::US9872852, Example 8

SMILES Cc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1

InChI Key InChIKey=QRXBPPWUGITQLE-UHFFFAOYSA-N

Data  15 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50239943   

TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  7.20E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD1/PDL1 interaction (unknown origin) after 15 mins by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of Ig-tagged human PD1/His-tagged human PDL1 interaction incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of human C-terminal Ig-Fc-tagged PD1 (Leu25 to Gln167 residues) expressed in HEK293 cells/human C-terminal epitope-His-tagged PDL1 (Phe19 ...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  780nMAssay Description:Inhibition of FC-tagged PD1/His-tagged PD-L1 (unknown origin) protein-proteiinteraction incubated for 3 hrs by coimmunoprecipitation-based Western bl...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD1-Tag2/PD-L1-Tag1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF binding assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  18nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair