BDBM50240996 CHEMBL4095093

SMILES Fc1ccc(Nc2ccc3c(OCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1ccccc1

InChI Key InChIKey=KZWLZLUTYGMNBM-UHFFFAOYSA-N

Data  2 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240996   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240996(CHEMBL4095093)
Affinity DataKd:  18nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240996(CHEMBL4095093)
Affinity DataIC50:  1nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240996(CHEMBL4095093)
Affinity DataIC50:  464nMAssay Description:Inhibition of P38 alpha MAPK in human whole blood assessed as reduction in TNF-alpha release after 10 mins by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240996(CHEMBL4095093)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair