BDBM50243980 3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL509435

SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12

InChI Key InChIKey=DUPIINAVKMGMHG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50243980   

TargetAurora kinase B(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human recombinant Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of human recombinant INS-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant ARK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human recombinant Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of human recombinant SAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant CDK4/cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243980(3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human recombinant CDK2/cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed