BDBM50245237 CHEMBL4074213::US11116757, No. A7

SMILES CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=VPHJABWIKCBGMC-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245237   

TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245237(CHEMBL4074213 | US11116757, No. A7)
Affinity DataIC50:  45nMAssay Description:Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245237(CHEMBL4074213 | US11116757, No. A7)
Affinity DataIC50:  170nMAssay Description:Inhibition of DCN1 (unknown origin) dependent cullin neddylation assessed as decrease in NEDD8 transfer from UBE2M to CUL2 using CUL2 as substrate pr...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50245237(CHEMBL4074213 | US11116757, No. A7)
Affinity DataIC50:  76.5nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair