BDBM50250896 CHEMBL4065346::US10696655, Example 52::US11168070, Example 52

SMILES CNC(=O)c1c[nH]c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F

InChI Key InChIKey=PQVUDEGEQFDCRY-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50250896   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataIC50:  9nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataIC50:  9nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair