BDBM50252142 (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(6-(4-methoxypiperidin-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one::CHEMBL519132

SMILES COC1CCN(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O

InChI Key InChIKey=AZFITEALNSCCOH-HSZRJFAPSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50252142   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252142((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  220nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252142((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252142((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  155nMAssay Description:Inhibition of IGF1R in mouse SAL cells assessed as thymidine incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed