BDBM50257916 CHEMBL493008::N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymethyl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide

SMILES CC(C)(O)Cn1c(NC(=O)c2ccc(s2)-c2cn[nH]c2)nc2cc(CN3CCCCC3CO)ccc12

InChI Key InChIKey=KMBKOQFKVOAXOC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257916   

TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 660nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed