BDBM50260029 CHEMBL4088388::US10370360, Example 40

SMILES C[C@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1

InChI Key InChIKey=FXWGWJNBGHQODS-IBGZPJMESA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50260029   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged c-kit cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system using Ser/Thr 6 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged DDR2 cytoplasmic domain expressed in baculovirus expression system using Fluorescein-Poly GAT as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50:  76nMAssay Description:Inhibition of recombinant human GST-tagged DDR1 catalytic domain expressed in baculovirus expression system using Fluorescein-Poly GAT as substrate m...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length His-tagged Bcr-Abl fusion protein cytoplasmic domain expressed in baculovirus expression system using tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50:  1.40E+3nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: >1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: >1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50:  66.2nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair