BDBM50269858 Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-cyclopropylcarbamoyl)-2-(2-fluoro-phenyl)-ethyl-ammonium

SMILES [NH3+][C@@H](Cc1ccccc1F)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N

InChI Key InChIKey=XIMJYDLECPMKMN-VDZJLULYSA-O

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50269858   

TargetNeutrophil elastase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  5.49E+3nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin G(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloblastin(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  4.55E+3nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: >220nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  1.90E+3nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  560nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50:  1.20E+3nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed