BDBM50279762 (5S)-9-chloro-5-methyl-6-(3-methylbut-2-enyl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione::(7R,8S)-4-Chloro-8-methyl-7-(3-methyl-but-2-enyl)-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione::(S)-4-Chloro-8-methyl-7-(3-methyl-but-2-enyl)-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione::(S)-7-Allyl-4-chloro-8-methyl-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione::14-(1-ethynyl)-9,15-dimethyl-(1S,9R,10R,11S,14R)-tetracyclo[8.7.0.02,7.011,15]heptadec-2(7)-en-14-ol::4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE::4-Chloro-8-methyl-7-(3-methyl-but-1-enyl)-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione::4-Chloro-8-methyl-7-(3-methyl-but-2-enyl)-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione(9-Cl TIBO)::7-Allyl-9-chloro-8-methyl-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulen-1-one::9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-tetrahydro-benzo[e][1,4]diazepine-2-thione::CHEMBL293498::R-82913

SMILES C[C@H]1CN2c3c(cc(cc3NC2=S)Cl)C[N@]1CC=C(C)C

InChI Key InChIKey=RCSLUNOLLUVOOG-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50279762   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataIC50: 15.5nMAssay Description:Tested for the inhibition of HIV-1 reverse transcriptase using a ribosomal RNA templateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2014
Entry Details Article

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataEC50:  33nMAssay Description:Effective concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataEC50:  60nMAssay Description:Effective concentration required against wild type HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataEC50:  5.60E+3nMAssay Description:Effective concentration required against L100I mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50279762(9-Chloro-5-methyl-6-(3-methyl-but-2-enyl)-1,5,6,7-...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed