BDBM50287579 CHEMBL4166936::US11572354, Compound 9k

SMILES Oc1cccc(Cn2cncc2-c2cc3cc(Br)ccc3[nH]2)c1

InChI Key InChIKey=FPUYNFZIGIXUCA-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287579   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287579(CHEMBL4166936 | US11572354, Compound 9k)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287579(CHEMBL4166936 | US11572354, Compound 9k)
Affinity DataIC50:  2.00E+3nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287579(CHEMBL4166936 | US11572354, Compound 9k)
Affinity DataEC50:  9.97E+3nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine production after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed