BDBM50295042 (S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta-[d]isoxazol-4-yl)propionic acid::CHEMBL553028

SMILES CC1CCC=C(C[C@H](N)C(O)=O)c2c1o[nH]c2=O

InChI Key InChIKey=OGDYFTNOLZTFCD-XDKWHASVSA-N

Data  7 KI  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50295042   

TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  5.08nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  1.38E+3nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR7A expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR4 flop isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR2(R) RNA-edited flop isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]KA from rat recombinant GluR6(VCR) RNA-edited isoform expressed in baculovirus infected Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  660nMAssay Description:Agonist activity at ConA-treated rat GluR5(Q) RNA-edited isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal curren...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  860nMAssay Description:Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  3.50E+4nMAssay Description:Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assa...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  4.80E+4nMAssay Description:Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assa...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  1.60E+5nMAssay Description:Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at ConA-treated rat NR1/NR2A expressed in Xenopus laevis oocytes assessed as glycine-induced maximal current by two-electrode voltag...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  7.00E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed