BDBM50315249 4-(3-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl)benzyl)morpholine::CHEMBL1089813

SMILES COc1cc(cc(OC)c1OC)-c1cnc2cccc(-c3ccc(CN4CCOCC4)cc3C)c2n1

InChI Key InChIKey=BJKIDAJALFVMDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315249   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315249(4-(3-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315249(4-(3-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315249(4-(3-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315249(4-(3-methyl-4-(3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50:  685nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed